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CSE 112 Mathematical Thinking
Office Hours: By Appointment
Room: PAB 334W
Center for Data-Driven Biosciences
Projects:
"Probing the origin of prion protein misfolding via reconstruction of ancestral
proteins"
"Model selection for single-molecule force spectroscopy data analysis"
"Models for analyzing single-molecule force spectroscopy data for the case of native state heterogeneity"
My view: (Please briefly describe your view on the three concepts below)
Short Bio:
Education:
ETH Zürich, Department of Biosystems Science and Engineering
Doctor of Sciences 2016
TU Dresden, Biotechnology Center
Master of Science 2011
Yerevan State University, Faculty of Physics
Bachelor of Physics 2009
Employment:
American University of Armenia, Akian College of Science and Engineering
Assistant Professor 2022 – present
University of Alberta, Department of Physics
Postdoctoral Fellow 2016 – 2022
ETH Zurich, Department of Biosystems Science and Engineering
Research Assistant 2012 – 2016
Leibniz Institute for Solid State and Materials Research
Student Assistant 2011
Publications:
R. Petrosyan, A. Narayan, and M. T. Woodside
“Single-molecule force spectroscopy of protein folding”
J. Mol. Biol. (2021) 433 (20), 167207.
R. Petrosyan, S. Patra, N. Rezajooei, C. Garen, and M.T. Woodside*
“Unfolded and intermediate states of PrP play a key role in the mechanism of action of an antiprion chaperone”
Proc. Natl. Acad. Sci. U.S.A. (2021) 118 (9), e2010213118.
R. Petrosyan*
“Unfolding force definition and the unified model for the mean unfolding force dependence on the loading rate”
J. Stat. Mech.: Theory Exp. (2020) (3), 033201.
D.A.N. Foster, R. Petrosyan, A.G.T. Pyo, A. Hoffmann, F. Wang, and M.T. Woodside*
“Probing position-dependent diffusion in folding reactions using single-molecule force spectroscopy”
Biophys. J. (2018) 114 (7), 1657-1666.
R. Petrosyan*
“Improved approximations for some polymer extension models”
Rheol. Acta (2017) 56 (1), 21-26.
R. Petrosyan, C.A. Bippes, S. Walheim, D. Harder, D. Fotiadis, T. Schimmel, D. Alsteens, and D.J. Müller*
“Single-molecule force spectroscopy of membrane proteins from membranes freely spanning across nanoscopic pores”
Nano Lett. (2015) 15 (5), 3624-3633.
E.P. Petrov*, R. Petrosyan, and P. Schwille
“Translational and rotational diffusion of micrometer-sized solid domains in lipid membranes”
Soft Matter (2012) 8 (29), 7552-7555.